| Information | |
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| has gloss | (noun) an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys" Cox-2 inhibitor |
| has gloss | eng: COX-2 selective inhibitor is a form of Non-steroidal anti-inflammatory drug (NSAID) that directly targets COX-2, an enzyme responsible for inflammation and pain. Selectivity for COX-2 reduces the risk of peptic ulceration, and is the main feature of celecoxib, rofecoxib and other members of this drug class. COX-2 selectivity does not seem to affect other adverse effects of NSAIDs (most notably an increased risk of renal failure), and some results have aroused the suspicion that there might be an increase in the risk for heart attack, thrombosis and stroke by a relative increase in thromboxane. Rofecoxib (commonly known as Vioxx) was taken off the market in 2004 because of these concerns. |
| lexicalization | eng: COX 2 inhibitor |
| lexicalization | eng: COX-2 inhibitors |
| lexicalization | eng: Cox-2 inhibitor |
| lexicalization | eng: Cox2 inhibitor |
| subclass of | (noun) a medicine intended to reduce inflammation anti-inflammatory, anti-inflammatory drug |
| has subclass | (noun) a Cox-2 inhibitor (trade name Celebrex) that relieves pain and inflammation without harming the digestive tract Celebrex, celecoxib |
| has subclass | (noun) a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004 rofecoxib, Vioxx |
| has subclass | (noun) a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract valdecoxib, Bextra |
| has instance | e/Discovery and development of cyclooxygenase 2 inhibitors |
| Meaning | |
|---|---|
| German | |
| has gloss | deu: Als COX-2-Hemmer oder auch COX-2-Inhibitor bezeichnet man eine Gruppe von entzündungshemmenden Arzneistoffen, bei der nur eine der Unterformen der Cyclooxygenase (COX) gehemmt wird. |
| lexicalization | deu: COX-2-Hemmer |
| French | |
| has gloss | fra: Les coxibs ou inhibiteurs COX-2 sélectifs sont une forme dAINS qui ciblent directement la COX-2, une enzyme responsable des états inflammatoires et de la douleur. On les utilise souvent dans le traitement de larthrite. |
| lexicalization | fra: coxib |
| Castilian | |
| has gloss | spa: Los inhibidores de la ciclooxigenasa 2 (COX-2), también llamados coxib, son antiinflamatorios no esteroideos (AINE) tan eficaces como el ácido acetilsalicílico, pero con menores efectos secundarios. Los inhibidores de la COX-2 se desarrollaron en un intento de inhibir la ciclooxigenasa 2 y con ella la síntesis de prostaciclina sin que tuviese efecto sobre la acción de la ciclooxigenasa 1 que se encuentra en el tracto gastrointestinal, riñones y plaquetas. |
| lexicalization | spa: Inhibidores selectivos de la COX 2 |
| lexicalization | spa: Inhibidores selectivos de la COX-2 |
| Turkish | |
| has gloss | tur: COX-2 selektif inhibitörleri yani koksibler bir çeşit Non steroidal antienflamatuar ilaçlardır ve direkt olarak ve enflamasyon ve ağrıdan sorumlu bir enzim olan COX-2yi inhibe ederek etkirler. COX-2 enzimine selektif olmaları nedeniyle peptik ülser riskini azaltırlar ve selekoksib, rofekoksib ve diğer grup elemanlarının üstün özelliğidir other members of this drug class. Cox-2-selektivitesi yan etkileri etkilemez ancak tromboz oluşumu , kalp krizi riskinde artış gibi şüphelerle 2004 yılında piyasadan çekilmişlerdir. |
| lexicalization | tur: Koksibler |
| Links | |
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| similar | e/Cox-2 inhibitor |
| Media | |
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| media:img | Rofecoxib.png |
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