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has gloss | (noun) a mouse with a genetic defect that prevents them from growing hair and also prevents them from immunologically rejecting human cells and tissues; widely used in preclinical trials nude mouse |
has gloss | eng: A nude mouse is a laboratory mouse from a strain with a genetic mutation that causes a deteriorated or absent thymus, resulting in an inhibited immune system due to a greatly reduced number of T cells. The phenotype, or main outward appearance of the mouse is a lack of body hair, which gives it the "nude" nickname. The nude mouse is valuable to research because it can receive many different types of tissue and tumor grafts, as it mounts no rejection response. These xenografts are commonly used in research to test new methods of imaging and treating tumors. The genetic basis of the nude mouse mutation is a disruption of the FOXN1 gene. |
lexicalization | eng: nude mouse |
subclass of | (noun) any of numerous small rodents typically resembling diminutive rats having pointed snouts and small ears on elongated bodies with slender usually hairless tails mouse |
Meaning | |
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Catalan | |
lexicalization | cat: ratolí nu |
German | |
has gloss | deu: Die Nacktmaus, auch thymusaplastische Maus oder athymische Maus genannt, ist ein genetischer Mutant der Hausmaus mit fehlendem Thymus. Der Phänotyp (das Aussehen) der Maus äußert sich durch ein Fehlen der Körperbehaarung, woraus sich ihr Name herleitet. Die Nacktmaus ist für die Forschung ein außerordentlich wichtiger Modellorganismus. |
lexicalization | deu: Nacktmaus |
Japanese | |
has gloss | jpn: ヌードマウスとは胸腺が劣化あるいは欠損したためにT細胞数の著しい減少が生じ、その結果として免疫系が阻害されている突然変異。ヌードマウスの表現型あるいは主要な外観として体毛の欠如があり、この特徴によりヌードマウスと名づけられた。ヌードマウスは異なる型の組織や腫瘍の移植に対して拒絶反応を示さないため、研究に有用である。それらの異種移植片は通常は腫瘍の新しい画像化や治療法の研究に利用される。ヌードマウスの遺伝的根拠はFOXN1遺伝子の破壊である 。 |
lexicalization | jpn: ヌードマウス |
Korean | |
lexicalization | kor: 누드마우스 |
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Show unreliable ▼ | |
similar | e/Nude mouse |
Media | |
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media:img | Nacktmaus 01.jpg |
media:img | Nacktmaus 02.jpg |
media:img | Nacktmaus 03.jpg |
media:img | Nude mouse.jpg |
media:img | PLoS One Nude Mouse PMID17342201.jpg |
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