s/n4013993

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has gloss(noun) an antiviral drug used against HIV; interrupts HIV replication by binding and blocking HIV protease; often used in combination with other drugs
protease inhibitor, PI
has glosseng: :For natural protease inhibitors, please see protease inhibitor (biology) Protease inhibitors (PIs) are a class of drugs used to treat or prevent infection by viruses, including HIV and Hepatitis C. PIs prevent viral replication by inhibiting the activity of HIV-1 protease, an enzyme used by the viruses to cleave nascent proteins for final assembly of new virons.
lexicalizationeng: PI
lexicalizationeng: Protease inhibitors
lexicalizationeng: protease inhibitor
subclass of(noun) any drug that destroys viruses
antiviral drug, antiviral agent, antiviral
has subclass(noun) a protease inhibitor (trade name Crixivan) used for treating HIV
indinavir, Crixivan
has subclass(noun) a protease inhibitor (trade name Viracept) used in treating HIV usually in combination with other drugs
nelfinavir, Viracept
has subclass(noun) a protease inhibitor (trade name Norvir) used in treating HIV
ritonavir, Norvir
has subclass(noun) a weak protease inhibitor (trade name Invirase) used in treating HIV
Invirase, saquinavir
has instancee/Direct Xa inhibitor
has instancee/Leupeptin
has instancee/Metalloprotease inhibitor
has instancee/Potato carboxypeptidase inhibitor
has instancee/Secretory leukocyte protease inhibitor
has instancee/Ulinastatin
Meaning
German
has glossdeu: Protease-Inhibitoren (PI) sind Moleküle, die Peptidasen (alter Name: Proteasen) hemmen und damit den Abbau von Proteinen verhindern können. Oft handelt es sich dabei selbst um Proteine. Auch eine Gruppe von Arzneistoffen, die zur Behandlung von HIV-Infektionen und allgemein gegen Retroviren eingesetzt werden (PI gegen das Hepatitis-C-Virus befinden sich im Entwicklungsstadium) werden als Proteaseinhibitoren bezeichnet. Des Weiteren gibt es auch körpereigene Substanzen, die körpereigenen Proteasen entgegen wirken (siehe auch Peptidasen und Peptidaseinhibitoren, wie z. B. Antitrypsin). Sowohl HIV-Proteasen als auch die körpereigenen Proteasen spielen eine wichtige Rolle bei der Krebsentstehung. Die synthetischen antiviralen Proteaseinhibitoren wirken, indem sie die virale Proteasen hemmen.
lexicalizationdeu: Protease-Inhibitor
lexicalizationdeu: Proteaseinhibitor
Finnish
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French
has glossfra: Les inhibiteurs de protéases (IP) inhibent un ou plus généralement plusieurs protéases voisines -il en existe une grande variété au niveau de la recherche-. Pour les applications pharmacologiques, les IPs, appelés communément antiprotéases, constituent la seconde classe dagents antirétroviraux à avoir été développée jusquau stade clinique (à commencer contre le VIH et le VHC). La première autorisation de mise sur le marché date de fin 1995. Elle a constitué un tournant majeur dans les stratégies thérapeutiques contre le VIH.
lexicalizationfra: Inhibiteur de la protéase
Indonesian
has glossind: Protease inhibitors adalah kelas dari pengobatan yang digunakan untuk menangani atau mencegah infeksi oleh virus, termasuk HIV dan Hepatitis C. Protease inhibitors mencegah replikasi virus dengan mencegah aktivitas HIV-1 protease, enzim yang digunakan oleh virus untuk membelah protein lahir untuk kumpulan akhir viron.
lexicalizationind: Protease inhibitor
Chinese
has glosszho: 蛋白酶抑制剂是带有环状结构的肽化合物,可竞争性或非竞争性抑制蛋白酶活性,此外,蛋白酶抑制剂还可以降低白介素-1β转换酶的表达,从而减少CD4细胞凋亡,FDA已批准上市7种药物(SQV、RTV、IDV、NFV、APV等)。
lexicalizationzho: 蛋白酶抑制剂
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part of(noun) a combination of protease inhibitors taken with reverse transcriptase inhibitors; used in treating AIDS and HIV
highly active antiretroviral therapy, HAART, drug cocktail
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similare/Protease inhibitor (pharmacology)

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